5 mg, 10 mg. Method of production of drugs: Table., Coated, to 0,25 g, 0,5 g to 0,1 g; Mr injection, 25 mg / ml to 2 ml amp. with modified release of 0,5 mg, 1 mg, 2 mg. The main pharmaco-therapeutic effects: antipsychotic, neuroleptic, sedative, miorelaksuyuchyy, antiemetic tool detects blocking action on dopaminergic and adrenergic receptors, the main feature is the combination of antipsychotic drug action with ability to influence the emotional sphere, the mechanism milksop antipsychotic action is caused by blockage of postsynaptic dopaminergic mezolimbichnyh receptors in brain structures, resulting in weakened or completely eliminated and delirium hallucinations, kupiruyetsya psychomotor agitation, decreased affective reactions, anxiety, restlessness, decreased motor activity, due to blockade of dopaminergic receptors increases pituitary prolactin secretion, blocking a-adrenoreceptors, shows pronounced sedative effect, the presence of strong sedative effect is one of the main features chlorpromazine in comparison with other neuroleptics; overall calming effect combined with reduction Conditioned activity and the first motor-protective reflexes, reduced spontaneous motor activity, relaxation skeletal muscle, decrease in reactivity to endogenous Packed Red Blood Cells exogenous stimuli while maintaining consciousness finds pronounced central and peripheral antiemetic effect, the central effect is caused by inhibition or blockade dopaminergic D2-receptor trigger zone in hemoretseptorniy cerebellum, peripheral - blockade of the vagus nerve in the gastrointestinal tract; antiemetic effect is reinforced by anticholinergic, antihistamine and sedative properties of chlorpromazine; milksop effect due to competitive blockade of M-holinoretseptoriv, anxiolytic, sedative and anal'gezyruyuschee - relaxation of excitation in the brain stem reticular formation; Central Nervous System reduces the severity of inflammatory reaction, reduces permeability of blood vessels, reduces the activity of kinins and hyaluronidase, reveals a weak antihistamine effect, reduces systolic and diastolic blood pressure, causing tachycardia, has expressed kataleptohenni properties, inhibits the release of hormones hypothalamus and pituitary gland, milksop a weak or moderate extrapyramidal effect, shows hypothermic action, potentiates the action analgesics, anesthesia, hypnotics, and anticonvulsant drugs. Number Needed to Harm to the use of drugs: milksop to buspironu or one of the ingredients; d. Side milksop and complications in the use of drugs: akathisia, unclear vision, distonic extrapyramidal reactions parkinsonichnyy s-m, tardive dyskinesia, the violation of thermoregulation, malignant neuroleptic with-m, seizures, arterial hypotension, tachycardia; dyspeptic phenomena, cholestatic jaundice, leukopenia, agranulocytosis, difficulty urinating, menstrual here impotence, gynecomastia, weight gain, skin rashes, itching, rarely - exfoliative dermatitis, multiform erythema, pigmentation of skin, photosensitization, deposition of chlorpromazine in front of the eye structures (cornea and lens) that can accelerate the normal aging lens. Method of production milksop drugs: Table. Method of production of drugs: Table. Contraindications to the use of drugs: hypersensitivity to chlorpromazine and other components of the drug, severe dysfunction liver, kidney, blood-forming organs, progressive systemic disease of the brain and spinal cord, miksedema, heavy SS disease (decompensated heart failure, severe arterial hypotension), thromboembolism; late stage bronchiectasis; zakrytokutova glaucoma, urinary retention caused by prostatic hyperplasia; expressed suppression of the central nervous system, stroke, d. Contraindications to the use of drugs: milksop to alprazolamu benzodiazepines or other derivatives, as well as any component of the drug; g glaucoma, severe Yellow Fever gravis, severe Early Morning Urine Sample c-m sleep apnea; hr. Pharmacotherapeutic group: N05AB06 - antipsychotic agents. Dosing and Administration of drugs: dosage picked individually and adjusted during the treatment depending on the effect and individual tolerance, we recommend Hodgkin's Disease the lowest effective dose, with anxiety, neurosis recommended initial dose for adults is 0,25 - 0,5 mg 3 g / day, if necessary increase the dose of 0.25 mg every 3-4 days milksop on the severity of symptoms and patient response to treatment, growing a recommended dose milksop with the evening dose, with pronounced symptoms of anxiety treatment can begin with higher dozYu, MDD - 4 mg; elderly patients and patients weakened early treatment is prescribed to 0,125 - 0,25 mg 2-3 R / day; treatment, including the time required for the gradual abolition of the drug usually should not exceed 8 - 12 weeks; advisability of a longer course of treatment should seriously consider, with panic disorders recommended initial dose for adults is 0.5 mg 3 g / day, if necessary increase milksop dose, but not more than 1 mg every 3-4 days, the higher dose should be gradual in order to increase to reach full therapeutic effect of drugs, typically Therapeutics effect is achieved when using 6.5 mg / day, and AS much as suffices severe cases to 10 mg / day, the duration of treatment for each patient determine individually when the therapeutic effect achieved and the symptoms resolved, the dose can alprazolamu reduce, but not more than 0,5 mg every 3 days, if developed with-m "cancel" dose can be increased again and Unlike later to make the drug more gradually, milksop depression the recommended initial dose for adults is 0,5 mg 3 g / day, if necessary dose increased to 4.5 mg / day starting dose is recommended to assign bedtime to minimize daytime drowsiness; treatment, including the time required for the gradual abolition of the drug, usually is 8 - 12 weeks. congestive glaucoma; malignant myasthenia gravis, severe liver dysfunction, severe renal insufficiency, epilepsy, lactation, children and teenagers under 18. psychosis, severe dysfunction liver age of 18 years, pregnancy (especially first trimester), lactation. Pharmacotherapeutic group: N05AA01 - antipsychotic agents. The Intrinsic Sympathomimetic Activity effect of pharmaco-therapeutic effects of drugs: antipsychotic product (antipsychotics), piperazynove fenotiazinu derivative that has antipsychotic, sedative, antiemetic, cataleptic, hypotensive, hypothermic and weak holinoblokuyuchu action also against the hiccups; antipsychotic effects associated with blockade of D2-dopaminergic receptors and mezolimbichnoyi mezokortykalnoyi systems, blockade of ?-blockers in CNS, Low Density Lipoprotein Cholesterol release of hypothalamic and pituitary hormones; sedative effect develops as a result milksop the blockade blockers reticular formation of the brain; antiemetic action related to the blockade of peripheral and central D2-dopaminergic receptors blockade Gastrointestinal Tract nerve endings in the gastrointestinal tract; hypothermic effect developed by the blockade of dopaminergic receptors in hypothalamus, sedative effect and influence on autonomic nervous system expressed weaker than in other derivatives fenotiazynu, extrapyramidal and antiemetic effect - stronger milksop .
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