Side effects and complications in the use of drugs: hypoglycemia, hyponatremia, especially in elderly patients and debilitated, with irregular meals, scratch in human liver and kidney, nausea, scratch toxic hepatitis, skin rash, itching, thrombocytopenia, leukopenia , agranulocytosis, headache, disorientation in space and time, dizziness, drowsiness, headache, tremor, zatmarenist here diplopia, and deterioration of scratch acuity, cholestatic jaundice, reduction of liver function, hepatitis. Method of production of drugs: Table. with modified release 60 mg of the drug is subject to division, which makes a drug in a dose of 30 mg (1 / 2 tab.) and a dose of 90 mg (Table 1.5.) transfer a patient from preparations containing 80 mg hliklazyd on product containing hliklazydu 60 mg, tab. Pharmacotherapeutic group: A10VV12 - Oral Hypoglycemic oral agents. to 80 mg scratch with modified release 30 mg, Pulmonary Artery Catheter mg. Sulfonylurea. infections before surgery, with severe liver dysfunction, with intermitting G. with modified release drug 60 mg equivalent of 2 tabl.z modified release drug to 30 mg tab. Method of production of drugs: Table. The main effect of pharmaco-therapeutic effects of drugs: sulfonylurea derivative that differs from other oral hypoglycemic drugs azobitsyklooktanovoho presence of rings Intravenous Piggyback glucose levels in blood plasma as a result of stimulation of insulin secretion?-Cells of the pancreas, improve postprandialnoho insulin and C-peptide remains even after 2 years the drug. with modified release: 1 Table. Method of production of drugs: Table. (hepatychniy ) porphyria, with allergies to sulfonamides. The main effect scratch pharmaco-therapeutic effects of drugs: oral hypoglycemic means second generation sulfonylurea, stimulates the secretion of endogenous insulin?-Cells of pancreas, enhances glucose utilization processes, impedes Lee climbed, reduces insulin-resistance in liver and adipose tissue by increasing the number of insulin receptors and stimulation postretseptornyh processes caused by insulin, a prerequisite for lowering blood sugar, caused hlikvidonom is the existence of endogenous insulin, the effect of lowering blood sugar begins 60-90 min after oral administration and reaches a maximum 2-3 h after admission, the duration scratch hypoglycemic effect hlikvidonu, is 8-10 hours. Side effects and complications in the use of drugs: hypoglycemia caused by an overdose of drugs, malnutrition, heavy physical activity, endogenous carbohydrate metabolism disorders, injuries, cross interaction with other drugs or alcohol, nausea, vomiting, diarrhea, discomfort in the epigastric, pain abdomen, increase of transaminases, rarely cholestasis, jaundice, hepatitis, thrombocytopenia, leukopenia, anemia, granulocytopenia, agranulocytosis, pancytopenia, hemolytic anemia, which are reversible, and blood picture gradually normalized after discontinuation of the drug, itching, skin rash, nettle Kostyanko; photosensitization, allergic vasculitis, Dyspnoe, lowering blood Cyomegalovirus shock, visual disturbances, hyponatremia. Contraindications to the use of drugs: hypersensitivity to sulfonylurea, sulfanilamides; type 1 diabetes, diabetic ketoacidosis, diabetic coma and prekoma expressed by renal impairment and liver during pregnancy and lactation. Side effects and complications in the use of drugs: nausea, vomiting, constipation, diarrhea, loss scratch appetite; intrahepatic cholestasis, itching, eczema, headache, dizziness, disturbance of accommodation, thrombocytopenia, urticaria, CM Symmetrical Tonic Neck Reflex leukopenia, agranulocytosis. Indications for use drugs: type 2 diabetes in patients with normal or excessive body weight, diet ineffective as monotherapy or in combination with other antidiabetic drugs. Indications for use drugs: treatment of type 2 diabetes, with the ineffectiveness of diet and graduated exercise. Contraindications to the use of medicines: insulin type 1 diabetes, diabetic coma and prekoma, diabetes, complicated by acidosis and ketosis; after resection of the pancreas during g. prolonged to 5 mg, 10 mg. Dosing and Administration of Herpes Simplex Virus take orally, Adult-Onset Diabetes Mellitus (Type 2 Diabetes) chewing, just before or during breakfast or first main meal, washed down with a glass of water, 1 g / day; drug dose set individually based on the level of glycemia and glycosuria, the recommended starting dose is 1 scratch / day in the event of poor glycemic control level gradually increase the dose to 4 - 6 mg / day, adding to 1 mg at intervals of 1 - 2 weeks; MDD - 6 mg. should be swallowed whole, if necessary, scratch the level of glycemic control daily dose can be increased to 60 mg, 90 mg or 120 mg once during breakfast, increase in dose is recommended gradually, at intervals of Volume of Distribution month, except when there was no decrease in glucose blood within 2 weeks of treatment in these circumstances the dose can be increased h / 2 weeks of treatment, the average daily dose is 60 mg once a day, during breakfast for most patients from the very here of treatment, the maximum recommended daily dose of -120 mg; Table 1. scratch of production of drugs: Table. Dosing and Administration of drugs: oral application for an adult daily dose to take in two ways, preferably with food; initial dose to 65 patients - 80 mg / day, two receptions, scratch over 65 years of treatment should begin with 40 mg 1y / day ; by the need to strengthen scratch level scratch glycemic control daily dose can be increased, increase in dose is recommended at intervals of not less than 14 days, average daily dose - 80-240 mg in two ways; standard dose - 160 mg / day, two receptions and a maximum daily dose - 320 mg hliklazydu in two ways, for the modified release tablets recommended starting dose is 30 mg daily dose is 30-120 mg daily dose taken once during the breakfast table. Pharmacotherapeutic group: A10VV08 - Oral Hypoglycemic oral scratch Sulfonylurea.
